Defiance Missouri Real Estate

Defiance is a small town located just about 40 miles West of St Louis.  It has been dubbed the “The Gateway to Missouri Wine Country“, and with good reason as the region is known for having some of the best vineyards in the Midwest.   See all the current Defiance MLS listings below, or read more about living in Defiance.  If you'd rather you can also search by map.

Homes For Sale in Defiance, MO

31 Properties Found. Page 1 of 2

Beautiful Acreage That Could Be Your Very Own "...

Photo of Listing #18039903

$2,288,000 Active

  • 104 Acres

Acreage & Farms

782 Matson Hill 104 Ac Rd, Defiance, MO

MLS® #18039903

Beautiful Acreage That Could Be Your Very Own "stay-cation" Or Close To Home Retreat. Approximately 104+/- Acre Parcel Of Land That Is So Serene And Spectacular That You Will Feel Like You Are On Vacation Every Time You Go. This Property Is Next To Matson H...

Situated In A Private Development W/many $1mill...

REDUCED 1% Photo of Listing #18079211

$934,500 Active

  • 4 Beds
  • 5 Baths
  • 4.45 Acres
  • 3,889 ft²

Residential

221 Northlind Dr, Defiance, MO

MLS® #18079211

Situated In A Private Development W/many $1million+ Homes, This Beautifully Maintained Home Sits On A Private 4.45 Acre Lot W/woods, Sprinkler, Fabulous L Shaped Salt Water Pool W/pool House, Hot Tub, Paver Patio, Screened In Porch! Impeccably Maintained 35...

Unique Custom Home, All Brick W/ Over 4,500 Sq ...

REDUCED 3% Photo of Listing #18057443

$899,900 Active

  • 4 Beds
  • 4 Baths
  • 12.85 Acres
  • 2,988 ft²

Residential

410 Holden Rd, Defiance, MO

MLS® #18057443

Unique Custom Home, All Brick W/ Over 4,500 Sq Ft. Of Living Space On 12.85 Stunning Acres W/ Your Own Lake! Welcome Home To This Unique Property That Features A 2 Story Rock Wall And Vaulted Tongue & Groove Pine Ceiling, Walls Of Windows Over Looking The P...

Exquisite 1.5 Sty With Over 5200 Sf Of Gorgeous...

Photo of Listing #19002072

$899,000 Active

  • 5 Beds
  • 5 Baths
  • 3 Acres
  • 4,073 ft²

Residential

1274 Kohlers Lane, Defiance, MO

MLS® #19002072

Exquisite 1.5 Sty With Over 5200 Sf Of Gorgeous Living Space, Sits On 3 Acres Of Private Woodland, Impressive Entry Sets The Way For The Elegance And Attention To Detail Throughout, Beamed Doorways & Ceiling, Acacia Hardwood Floors, Uv Protected Windows, Cu...

Just Listed! New 4 Bedroom, 4.5 Bath Split Bedr...

Photo of Listing #19002128

$889,500 Active

  • 4 Beds
  • 5 Baths
  • 3.23 Acres
  • 3,099 ft²

Residential

3725 Toedebusch Rd, Defiance, MO

MLS® #19002128

Just Listed! New 4 Bedroom, 4.5 Bath Split Bedroom Ranch Inventory Home By Js Clement Construction Now Under Construction At White Heron Estates. Picturesque 3+ Acre Home Site. Exceptional Quality W/impressive High End Features & Finishes. Brick & Stone Fro...

Welcome To The Yellow Farmhouse Vineyard! Featu...

REDUCED 2% Photo of Listing #18004442

$855,000 Active

  • 7.04 Acres

Commercial & Indr.

100 Defiance Rd Unit 6.84ac, Defiance, MO

MLS® #18004442

Welcome To The Yellow Farmhouse Vineyard! Features 2 Homes, Tasting & Storage Room, Outdoor Pavilion & So Much More. It Sits On The 4 Corners Of Defiance Facing The Missouri River W/gorgeous Views. The Main House Feat 2 Decks, Full Kitchen, Dining/rec Room,...

Simply Amazing! This Huge 3 Bed/3.5 Bath Brick ...

Photo of Listing #18084213

$700,000 Active

  • 3 Beds
  • 4 Baths
  • 3.01 Acres
  • 3,398 ft²

Residential

321 Matts Way, Defiance, MO

MLS® #18084213

Simply Amazing! This Huge 3 Bed/3.5 Bath Brick Front Custom-built Ranch Rests Upon A Sprawling 3 Acre Gently Rolling Lot Backing To Woods. The Open Floorplan Greets You W Hardwood Flooring In The Entry & A Soaring Cathedral Ceiling Stretching Rising Above T...

Lot F In Saddleback Subdivision - Defiance, Mo ...

Photo of Listing #18076692

$614,323 Active

  • 24.57 Acres

Acreage & Farms

1 A Boone Ridge Trail, Defiance, MO

MLS® #18076692

Lot F In Saddleback Subdivision - Defiance, Mo - This Lot Is Located In The Beautiful Saddleback Subdivision. The Lot Is Totally Wooded And Private. This Lot Has Access To A 70 Acre Lake And A Dock Will Be Provided For This Lot. This Lot Has A Flat, Wooded,...

Don't Miss This Beautiful Lake Front Home Sitti...

REDUCED 2% Photo of Listing #18041904

$575,000 Active

  • 3 Beds
  • 3 Baths
  • 6.88 Acres
  • 2,689 ft²

Residential

687 Boone Ridge Trail, Defiance, MO

MLS® #18041904

Don't Miss This Beautiful Lake Front Home Sitting On 6.88 Acres In Saddleback Subdivision. Saddleback Is Well Known For Its Amazing Lake, Amazing Sunrises And Sunsets In The Middle Of Wine Country And So Close To Many Area Parks. This Home Includes: Hardw...

Tract 6 In Saddleback Subdivision - Defiance, M...

Photo of Listing #18076686

$506,500 Active

  • 20.26 Acres

Acreage & Farms

4 D Boone Ridge Trail, Defiance, MO

MLS® #18076686

Tract 6 In Saddleback Subdivision - Defiance, Mo - This Lot Is Located In The Beautiful Saddleback Subdivision. The Lot Is Totally Wooded And Private. This Lot Has Access To A 70 Acre Lake And A Dock Will Be Provided For This Lot. This Lot Has A Flat, Woode...

What An Awesome Opportunity, This Property Is S...

REDUCED 10% Photo of Listing #18053694

$475,000 Active

  • 21.73 Acres

Acreage & Farms

35 Neal Lane, Defiance, MO

MLS® #18053694

What An Awesome Opportunity, This Property Is Situated In Heart Of Sought-after Defiance Mo. Has Hwy 94 Access With Public Water Available At Hwy 94. Located Close To Busch Wildlife, Broemmelsiek Park, Katy Trail And Many Wineries Nearby. This Gorgeous 22 ...

Just Past The Daniel Boone Home, And Hidden Awa...

REDUCED 1% Photo of Listing #18076694

$460,000 Active

  • 4 Beds
  • 3 Baths
  • 5.03 Acres
  • 2,500 ft²

Residential

2 Horn Cove Lane, Defiance, MO

MLS® #18076694

Just Past The Daniel Boone Home, And Hidden Away On 5 Acres In The Heart Of Wine Country Is This Charming 4 Bedroom Home That Boasts All The Lastest Updates. Enjoy The Most Picture-perfect Sunsets & Boundless Outdoor Space. 70 Acre Subdivision Lake. Check...

If You Are Looking For An Absolutely Stunning R...

REDUCED 1% Photo of Listing #18082244

$440,000 Active

  • 5 Beds
  • 3 Baths
  • 3.6 Acres
  • 3,600 ft²

Residential

3870 Ridgefield Farms, Defiance, MO

MLS® #18082244

If You Are Looking For An Absolutely Stunning Ranch Home Nestled On 3.6 Acres In A Subdivision W Public Water Close To Missouri Wine Country, Then Look No Further!! Beautiful Curb Appeal.hardwood Flooring Greets You As You Enter.notice The Great Room W Vaul...

Nature Is Calling! The Tranquility And Vibrancy...

NEW Photo of Listing #19000230

$399,900 Active

  • 3 Beds
  • 3 Baths
  • 3.2 Acres
  • 2,486 ft²

Residential

194 Quail Run Dr, Defiance, MO

MLS® #19000230

Nature Is Calling! The Tranquility And Vibrancy Of Nature Surround You Each Day. Coming Home Is Really More Like Escaping To Your Own Private Ozark Retreat. The Setting Is Magnificent, The Welcoming Interior Of This Home Is Equally Appealing. Floor Plan Is ...

Tract 8 In Saddleback Subdivision - Defiance, M...

Photo of Listing #18076690

$381,625 Active

  • 15.27 Acres

Acreage & Farms

5 E Boone Ridge Trail, Defiance, MO

MLS® #18076690

Tract 8 In Saddleback Subdivision - Defiance, Mo - This Lot Is Located In The Beautiful Saddleback Subdivision. The Lot Is Totally Wooded And Private. This Lot Has Access To A 70 Acre Lake And A Dock Will Be Provided For This Lot. This Lot Has A Flat, Woode...

Tract 9 In Saddleback Subdivision - Defiance, M...

Photo of Listing #18076691

$332,425 Active

  • 13.3 Acres

Acreage & Farms

6 F Boone Ridge Trail, Defiance, MO

MLS® #18076691

Tract 9 In Saddleback Subdivision - Defiance, Mo -this Lot Is Located In The Beautiful Saddleback Subdivision. The Lot Is Totally Wooded And Private. This Lot Has Access To A 70 Acre Lake And A Dock Will Be Provided For This Lot. This Lot Has A Flat, Wooded...

Located In Unincorporated St. Charles County Th...

Photo of Listing #18066997

$179,900 Active

  • 14.37 Acres

Acreage & Farms

Steeple Rock, Defiance, MO

MLS® #18066997

Located In Unincorporated St. Charles County This 14.37 Surveyed Wooded Acres Offers Great Opportunity. Deer And Turkey Have Called This Vacant Block Of Timber Home For Many Years. A Great Location To Build Your Wooded Country Living Residence Or Weekend Ge...


Living in Defiance, MO

There are various places of importance in close proximity to Defiance; they are the Yellow Farmhouse Vineyard and Winery, Historic Daniel Boone Home and Boonesfield Village, and Frisella Nursery. Many people travel to this area to visit the historic site of Daniel Boone’s home.  This old home was constructed in the early 1800’s and has thick limestone walls. Listed as a home on the National Register of Historic Places, this extraordinary site is often frequented by those new to the area.  Today, this village is owned and run by the Lindenwood University.  It is one of the great sites that depict life in this time period and give a glimpse into the American frontier experience.

History of Defiance

Around the turn of the century, the little town of Defiance, MO was formed. This area had no name but big plans, as the Katy Railroad began installing a rail system through this region. The unnamed town needed a title with its progress and plans for further development.  Town officials wanted to use the name Parsons, after the man who laid the railroad. The name was quickly turned down due to another town on the Katy Line with the same label.  The Matson Brothers tried to stop the progress in this town, and thus the town was named “Defiance” because they defied the Matson’s and allowed progress to continue.

Defiance Schools

There are no local schools in Defiance due to the small nature of this community. Students living in this area attend the Warrenton school district. There are five public schools that are divided by age groups K-12th.  There are five elementary schools, two middles schools and one high school in Warrenton. Each of the elementary schools has around 450 students and the high school has 930.  The class sizes are rather small with 15 students per teacher.  By having smaller class sizes, Warrenton can ensure that their students are getting a quality education and get the one-on-one interaction that they need.

Contact us today at 314-282-8282 for more information about living in Defiance.

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