Defiance Missouri Real Estate

Defiance is a small town located just about 40 miles West of St Louis.  It has been dubbed the “The Gateway to Missouri Wine Country“, and with good reason as the region is known for having some of the best vineyards in the Midwest.   See all the current Defiance MLS listings below, or read more about living in Defiance.  If you'd rather you can also search by map.

Homes For Sale in Defiance, MO

39 Properties Found. Page 1 of 3

Beautiful Acreage That Could Be Your Very Own "...

Photo of Listing #18039903

$2,288,000 Active

  • 104 Acres

Acreage & Farms

782 Matson Hill 104 Ac Rd, Defiance, MO

MLS® #18039903

Beautiful Acreage That Could Be Your Very Own "stay-cation" Or Close To Home Retreat. Approximately 104+/- Acre Parcel Of Land That Is So Serene And Spectacular That You Will Feel Like You Are On Vacation Every Time You Go. This Property Is Next To Matson H...

Exquisite Design, Elegant Details In The Gorgeo...

Photo of Listing #18049751

$1,289,000 Active

  • 5 Beds
  • 7 Baths
  • 2.86 Acres
  • 3,326 ft²

Residential

220 Northlind Dr, Defiance, MO

MLS® #18049751

Exquisite Design, Elegant Details In The Gorgeous Custom Built Estate. The Brick/stone Elevation, Stone Walk Over Water Fall, Motor Court With Attached 3 Car Oversized Garage Plus Detached 52 X 40 *8 Car Garge (4 Car Two Deep) Plus Office /living Quarters A...

This Gorgeous Home Is Located Minutes From Ches...

Photo of Listing #18027028

$1,249,000 Active

  • 4 Beds
  • 6 Baths
  • 3 Acres
  • 2,250 ft²

New Construction

2 Lauderdale Lane, Defiance, MO

MLS® #18027028

This Gorgeous Home Is Located Minutes From Chesterfield Valley. Serenity Is Provided At This Peaceful Home Site In The Development Of, The Crossings At Lauderdale Estates. The Exterior Of This Home Has A "big Cedar Lodge" Timber Look And Provides An Enterta...

Situated In A Private Development W/many $1mill...

Photo of Listing #18079211

$939,500 Active

  • 4 Beds
  • 5 Baths
  • 4.45 Acres
  • 3,889 ft²

Residential

221 Northlind Dr, Defiance, MO

MLS® #18079211

Situated In A Private Development W/many $1million+ Homes, This Beautifully Maintained Home Sits On A Private 4.45 Acre Lot W/woods, Sprinkler, Fabulous L Shaped Salt Water Pool W/pool House, Hot Tub, Paver Patio, Screened In Porch! Impeccably Maintained 35...

Unique Custom Home, All Brick W/ Over 4,500 Sq ...

REDUCED 7% Photo of Listing #18057443

$925,000 Active

  • 4 Beds
  • 4 Baths
  • 12.85 Acres
  • 2,988 ft²

Residential

410 Holden Rd, Defiance, MO

MLS® #18057443

Unique Custom Home, All Brick W/ Over 4,500 Sq Ft. Of Living Space On 12.85 Stunning Acres W/ Your Own Lake! Welcome Home To This Unique Property That Features A 2 Story Rock Wall And Vaulted Tongue & Groove Pine Ceiling, Walls Of Windows Over Looking The P...

Welcome To The Yellow Farmhouse Vineyard! Featu...

REDUCED 13% Photo of Listing #18004442

$875,000 Active

  • 7.04 Acres

Commercial & Indr.

100 Defiance Rd Unit 6.84ac, Defiance, MO

MLS® #18004442

Welcome To The Yellow Farmhouse Vineyard! Features 2 Homes, Tasting & Storage Room, Outdoor Pavilion & So Much More. It Sits On The 4 Corners Of Defiance Facing The Missouri River W/gorgeous Views. The Main House Feat 2 Decks, Full Kitchen, Dining/rec Room,...

Simply Amazing! This Huge 3 Bed/3.5 Bath Brick ...

Photo of Listing #18084213

$700,000 Active

  • 3 Beds
  • 4 Baths
  • 3.01 Acres
  • 3,398 ft²

Residential

321 Matts Way, Defiance, MO

MLS® #18084213

Simply Amazing! This Huge 3 Bed/3.5 Bath Brick Front Custom-built Ranch Rests Upon A Sprawling 3 Acre Gently Rolling Lot Backing To Woods. The Open Floorplan Greets You W Hardwood Flooring In The Entry & A Soaring Cathedral Ceiling Stretching Rising Above T...

Lot F In Saddleback Subdivision - Defiance, Mo ...

Photo of Listing #18076692

$614,323 Active

  • 24.57 Acres

Acreage & Farms

1 A Boone Ridge Trail, Defiance, MO

MLS® #18076692

Lot F In Saddleback Subdivision - Defiance, Mo - This Lot Is Located In The Beautiful Saddleback Subdivision. The Lot Is Totally Wooded And Private. This Lot Has Access To A 70 Acre Lake And A Dock Will Be Provided For This Lot. This Lot Has A Flat, Wooded,...

Don't Miss This Beautiful Lake Front Home Sitti...

REDUCED 2% Photo of Listing #18041904

$575,000 Active

  • 3 Beds
  • 3 Baths
  • 6.88 Acres
  • 2,689 ft²

Residential

687 Boone Ridge Trail, Defiance, MO

MLS® #18041904

Don't Miss This Beautiful Lake Front Home Sitting On 6.88 Acres In Saddleback Subdivision. Saddleback Is Well Known For Its Amazing Lake, Amazing Sunrises And Sunsets In The Middle Of Wine Country And So Close To Many Area Parks. This Home Includes: Hardw...

This Impressive, Rambling 1.5 Story Home With W...

Photo of Listing #18057350

$550,000 Active

  • 4 Beds
  • 5 Baths
  • 10 Acres
  • 2,989 ft²

Residential

212 Deep Forest Lane, Defiance, MO

MLS® #18057350

This Impressive, Rambling 1.5 Story Home With Wrap Around Porch Is Snuggled Into The Beautiful Boone Valley Area Situated On 10 Lush Ac With Two Ponds, Woods, Open Ground, Mother Nature & Privacy*as You Enter The Home Large Entry Way Will Draw Your Eyes To ...

What An Awesome Opportunity, This Property Is S...

REDUCED 9% Photo of Listing #18053694

$525,000 Active

  • 21.73 Acres

Acreage & Farms

35 Neal Lane, Defiance, MO

MLS® #18053694

What An Awesome Opportunity, This Property Is Situated In Heart Of Sought-after Defiance Mo. Has Hwy 94 Access With Public Water Available At Hwy 94. Located Close To Busch Wildlife, Broemmelsiek Park, Katy Trail And Many Wineries Nearby. This Gorgeous 22 ...

Tract 6 In Saddleback Subdivision - Defiance, M...

Photo of Listing #18076686

$506,500 Active

  • 20.26 Acres

Acreage & Farms

Boone Ridge Trail, Defiance, MO

MLS® #18076686

Tract 6 In Saddleback Subdivision - Defiance, Mo - This Lot Is Located In The Beautiful Saddleback Subdivision. The Lot Is Totally Wooded And Private. This Lot Has Access To A 70 Acre Lake And A Dock Will Be Provided For This Lot. This Lot Has A Flat, Woode...

Just Past The Daniel Boone Home, And Hidden Awa...

REDUCED 2% Photo of Listing #18076694

$475,000 Active

  • 4 Beds
  • 3 Baths
  • 5.03 Acres
  • 2,500 ft²

Residential

2 Horn Cove Lane, Defiance, MO

MLS® #18076694

Just Past The Daniel Boone Home, And Hidden Away On 5 Acres In The Heart Of Wine Country Is This Charming 4 Bedroom Home That Boasts All The Lastest Updates. Enjoy The Most Picture-perfect Sunsets & Boundless Outdoor Space. 80 Acre Subdivision Lake. Check...

Private Wooded Lot, Covered Front Porch Overloo...

Photo of Listing #18046855

$429,000 Active

  • 5 Beds
  • 2 Baths
  • 3.56 Acres
  • 2,755 ft²

Residential

163 Quail Run, Defiance, MO

MLS® #18046855

Private Wooded Lot, Covered Front Porch Overlooks 2 Landscaped Fish Ponds Connected By Waterfalls And Flower Gardens. Heavy Trees, Gorgeous View From Large New Deck 2018. Hardwood Flooring Throughout The Main Level. Soaring Vaulted Family Room With Fireplac...

Tract 8 In Saddleback Subdivision - Defiance, M...

Photo of Listing #18076690

$381,625 Active

  • 15.27 Acres

Acreage & Farms

Boone Ridge Trail, Defiance, MO

MLS® #18076690

Tract 8 In Saddleback Subdivision - Defiance, Mo - This Lot Is Located In The Beautiful Saddleback Subdivision. The Lot Is Totally Wooded And Private. This Lot Has Access To A 70 Acre Lake And A Dock Will Be Provided For This Lot. This Lot Has A Flat, Woode...

Stunning 4 Bedroom, 2 Full/2 Half Bath, 2 Story...

REDUCED 1% Photo of Listing #18076494

$375,000 Active

  • 4 Beds
  • 4 Baths
  • 3.32 Acres
  • 2,866 ft²

Residential

27 Large Mouth Ct, Defiance, MO

MLS® #18076494

Stunning 4 Bedroom, 2 Full/2 Half Bath, 2 Story Home Located On A Cul-de-sac, 3+ Acre Lot & With Rights To The Subdivisions Private 160 Acre Lake For Fishing, Boating, Sandy Beach Area For Picnics, Swimming & More. Beautiful Front Exterior With Pond & Cove...

Winter Special Price Reduction! Because Home Is...

REDUCED 4% Photo of Listing #18064914

$359,999 Active

  • 3 Beds
  • 3 Baths
  • 3 Acres
  • 2,500 ft²

Residential

224 Quail Run, Defiance, MO

MLS® #18064914

Winter Special Price Reduction! Because Home Is Where Your Story Begins! Relax W/ The Peaceful Country Setting Where Life Just Moves A Little Slower. You Pull Up To This Meticulously Maintained Home That Is Nestled On A Wooded Lot With A Million Dollar View...


Living in Defiance, MO

There are various places of importance in close proximity to Defiance; they are the Yellow Farmhouse Vineyard and Winery, Historic Daniel Boone Home and Boonesfield Village, and Frisella Nursery. Many people travel to this area to visit the historic site of Daniel Boone’s home.  This old home was constructed in the early 1800’s and has thick limestone walls. Listed as a home on the National Register of Historic Places, this extraordinary site is often frequented by those new to the area.  Today, this village is owned and run by the Lindenwood University.  It is one of the great sites that depict life in this time period and give a glimpse into the American frontier experience.

History of Defiance

Around the turn of the century, the little town of Defiance, MO was formed. This area had no name but big plans, as the Katy Railroad began installing a rail system through this region. The unnamed town needed a title with its progress and plans for further development.  Town officials wanted to use the name Parsons, after the man who laid the railroad. The name was quickly turned down due to another town on the Katy Line with the same label.  The Matson Brothers tried to stop the progress in this town, and thus the town was named “Defiance” because they defied the Matson’s and allowed progress to continue.

Defiance Schools

There are no local schools in Defiance due to the small nature of this community. Students living in this area attend the Warrenton school district. There are five public schools that are divided by age groups K-12th.  There are five elementary schools, two middles schools and one high school in Warrenton. Each of the elementary schools has around 450 students and the high school has 930.  The class sizes are rather small with 15 students per teacher.  By having smaller class sizes, Warrenton can ensure that their students are getting a quality education and get the one-on-one interaction that they need.

Contact us today at 314-282-8282 for more information about living in Defiance.

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