Defiance Missouri Real Estate

Defiance is a small town located just about 40 miles West of St Louis.  It has been dubbed the “The Gateway to Missouri Wine Country“, and with good reason as the region is known for having some of the best vineyards in the Midwest.   See all the current Defiance MLS listings below, or read more about living in Defiance.  If you'd rather you can also search by map.

Homes For Sale in Defiance, MO

37 Properties Found. Page 1 of 3

Beautiful Acreage That Could Be Your Very Own "...

NEW Photo of Listing #18039903

$2,288,000 Active

  • 104 Acres

Acreage & Farms

782 Matson Hill 104 Ac Rd, Defiance, MO

MLS® #18039903

Beautiful Acreage That Could Be Your Very Own "stay-cation" Or Close To Home Retreat. Approximately 104+/- Acre Parcel Of Land That Is So Serene And Spectacular That You Will Feel Like You Are On Vacation Every Time You Go. This Property Is Next To Matson H...

90.57 +/- Acres Of Open And Wooded Ground. Acce...

Photo of Listing #18007816

$2,264,250 Active

  • 90.57 Acres

Acreage & Farms

S Hwy 94, Defiance, MO

MLS® #18007816

90.57 +/- Acres Of Open And Wooded Ground. Access To The Katy Trail From The South End Of The Property, Some Of This Section Is In The Flood Plain. Located Near Klondike Park, Weldon Spring Conservation Area And Lost Valley Hiking Trails. Close To Several...

You Can Have It All! Majestic European Manse Is...

NEW Photo of Listing #18033930

$1,499,000 Active

  • 5 Beds
  • 5 Baths
  • 4.1 Acres
  • 5,324 ft²

Residential

461 Matts Way, Defiance, MO

MLS® #18033930

You Can Have It All! Majestic European Manse Is The Best Of Both Worlds – Plenty Of Room To Roam, Close To Wine Country, And Yet Just 15 Minutes To Chesterfield Valley And 35 Minutes To Downtown Clayton! There Is Truly Nothing Else Like It. From The Rotunda...

Beautiful Historic Farm With Highway F Road Fro...

REDUCED 15% Photo of Listing #17009255

$1,373,750 Active

  • 157 Acres

Acreage & Farms

1403 Highway F 157+/- Acres, Defiance, MO

MLS® #17009255

Beautiful Historic Farm With Highway F Road Frontage Near Augusta. Property Suitable For Horses, Cattle, With Cropland, Pasture, And Woods. Femme Osage Creek Running Through Property. Rolling And Hilly Agricultural Land. 157ac

This Gorgeous Home Is Located Minutes From Ches...

Photo of Listing #18027028

$1,249,000 Active

  • 4 Beds
  • 6 Baths
  • 3 Acres

New Construction

2 Lauderdale Lane, Defiance, MO

MLS® #18027028

This Gorgeous Home Is Located Minutes From Chesterfield Valley. Serenity Is Provided At This Peaceful Home Site In The Development Of, The Crossings At Lauderdale Estates. The Exterior Of This Home Has A "big Cedar Lodge" Timber Look And Provides An Enterta...

Welcome To The Yellow Farmhouse Vineyard! Featu...

Photo of Listing #18004442

$1,000,000 Active

  • 7.04 Acres

Commercial & Indr.

100 Defiance Rd Unit 6.84ac, Defiance, MO

MLS® #18004442

Welcome To The Yellow Farmhouse Vineyard! Features 2 Homes, Tasting & Storage Room, Outdoor Pavilion & So Much More. It Sits On The 4 Corners Of Defiance Facing The Missouri River W/gorgeous Views. The Main House Feat 2 Decks, Full Kitchen, Dining/rec Room,...

Unbelievable Views Abound From This 50+/- Acres...

Photo of Listing #17052062

$975,000 Active

  • 50 Acres

Acreage & Farms

S Hwy 94, Defiance, MO

MLS® #17052062

Unbelievable Views Abound From This 50+/- Acres Overlooking The Mo River Bottoms And A Peak At St. Albans Bluffs. You Won't Be Able To Wait To Clear Additional Trees And Build Your Dream Home Here. This Parcel Has Been A Part Of The Daniel Boone's History A...

Welcome To Wine Country! Luxury Estate Located ...

Photo of Listing #18032519

$949,500 Active

  • 4 Beds
  • 5 Baths
  • 4.45 Acres
  • 3,889 ft²

Residential

221 Northlind Dr, Defiance, MO

MLS® #18032519

Welcome To Wine Country! Luxury Estate Located In Gorgeous Defiance, Mo Sits On 4.5 Beautiful Acres, Is Loaded With Upgrades And Would Make The Perfect Forever Home For Discerning Buyers! This Home Truly Has It All With Amazing Curb Appeal And Matching Det...

New 4,176 Sq Ft 1.5 Story Home By Js Clement Co...

NEW Photo of Listing #18040650

$949,000 Active

  • 4 Beds
  • 4 Baths
  • 3 Acres
  • 4,176 ft²

Residential

105 White Heron Lane, Defiance, MO

MLS® #18040650

New 4,176 Sq Ft 1.5 Story Home By Js Clement Construction Now Completed On 3 Acres At White Heron Estates. Exceptional Quality And Impressive High End Features And Finishes. Full Brick & Stone Front Elevation, James Hardie Siding, Pella Windows, Custom I...

Impressive Custom Home Offers Exceptional Quali...

Photo of Listing #18018351

$799,000 Active

  • 5 Beds
  • 4 Baths
  • 3 Acres
  • 3,259 ft²

Residential

4465 Wilson Rd, Defiance, MO

MLS® #18018351

Impressive Custom Home Offers Exceptional Quality W/high End Features, Finishes With Attention To Detail Throughout. An Exquisite 5bd/3.5bath Home At Just Under 4750sqft Of Living Space Including 2 Full Gourmet Kitchens. What A Grand Entrance, Travertine Ti...

Defiance, Francis Howell Schools; Custom Built ...

NEW Photo of Listing #18040719

$699,900 Active

  • 4 Beds
  • 5 Baths
  • 3 Acres
  • 4,000 ft²

Residential

1277 August Lake Ct, Defiance, MO

MLS® #18040719

Defiance, Francis Howell Schools; Custom Built 1.5 Story On 3 Quiet Acres In Defiance; Beautiful Features Throughout Include Tray Ceilings, Arched Doorways, Crown Molding, Built-in Shelving And Built-in Sound System On Main Floor/ul Bonus Room; Two-story Fo...

Fantastic Custom Home! All Brick With Over 4,50...

Photo of Listing #18010081

$649,500 Active

  • 4 Beds
  • 4 Baths
  • 6 Acres
  • 2,988 ft²

Residential

410 Holden Rd, Defiance, MO

MLS® #18010081

Fantastic Custom Home! All Brick With Over 4,500 Sq Ft. Of Liv Space Nestled On 6 Picturesque Acres. Magnificent 2 Story Rock Wall, Vaulted Tongue And Groove Pine Ceiling & Walls Of Windows Are Just A Few Of The Features That Greet You. Great Room Features ...

Wonderful 4 Bedroom, 3 ½ Bath, 2-story Home On ...

NEW Photo of Listing #18033394

$495,000 Active

  • 4 Beds
  • 4 Baths
  • 3.02 Acres
  • 2,332 ft²

Residential

1329 Lakeway Dr, Defiance, MO

MLS® #18033394

Wonderful 4 Bedroom, 3 ½ Bath, 2-story Home On A 3+ Acre Lot. Warm Hardwood Floors Greet You At The Entry And Carry You Into The Soaring 2-story Cathedral Vaulted Great Room. The Wood-burning Fireplace Is Perfect For Gathering. Large Windows Here And In The...

Beautiful Stand Alone 13 Ac Tract In One Of St ...

Photo of Listing #18028916

$467,000 Active

  • 13.36 Acres

Acreage & Farms

13-ac Toedebusch Rd, Defiance, MO

MLS® #18028916

Beautiful Stand Alone 13 Ac Tract In One Of St Charles Counties Most Prestigious Zip Codes. Located Near Wine Country, Broemmelsiek Park, Busch Wildlife Area And 5 Minutes To I-64 At Wing Haven. Gently Rolling To Level Ground With Scattered Tree Line. Lake ...

Fantastic 4br 2.5 Ba 2 Sty On 3+ Acres In Quiet...

REDUCED 2% Photo of Listing #18029473

$464,900 Active

  • 4 Beds
  • 3 Baths
  • 3 Acres
  • 3,837 ft²

Residential

887 Jacks Creek Ct, Defiance, MO

MLS® #18029473

Fantastic 4br 2.5 Ba 2 Sty On 3+ Acres In Quiet Cul-de-sac! 2sty Entry To Formal Living & Dining Room. All New Lighting Throughout. New Carpet On Main Level. Sunlit Family Room W/fireplace. Huge Kitchen/breakfast/hearth Room W/2nd Cozy Fireplace...upscale ...

Perfect Rustic Home 4100+ Sf On 3.1 Acres Is Wa...

REDUCED 1% Photo of Listing #18029822

$454,000 Active

  • 4 Beds
  • 4 Baths
  • 3.1 Acres
  • 2,666 ft²

Residential

13 Pine Cliff Ct, Defiance, MO

MLS® #18029822

Perfect Rustic Home 4100+ Sf On 3.1 Acres Is Warm And Inviting From The Beautiful Brick Front Elevation, Updated Architectural Roof, To The Charming 3 Seasons Room With A Great View Of The Property That Extends 25' On Left Past The Ravine. Enjoy The Outdoor...

Attention Builders! Possible Division Would ...

Photo of Listing #17072446

$449,000 Active

  • 51.29 Acres

Residential Lots

14-lots Udall Ct., Defiance, MO

MLS® #17072446

Attention Builders! Possible Division Would Make 14 3acre Lots. Desirable Large Wooded Parcel Of 51 +- Acres In St. Charles County Has Open Slate Of Possibilities. Would Make For An Excellent Development Parcel. Engineering And Soil Tests For 3 Acre Lots...


Living in Defiance, MO

There are various places of importance in close proximity to Defiance; they are the Yellow Farmhouse Vineyard and Winery, Historic Daniel Boone Home and Boonesfield Village, and Frisella Nursery. Many people travel to this area to visit the historic site of Daniel Boone’s home.  This old home was constructed in the early 1800’s and has thick limestone walls. Listed as a home on the National Register of Historic Places, this extraordinary site is often frequented by those new to the area.  Today, this village is owned and run by the Lindenwood University.  It is one of the great sites that depict life in this time period and give a glimpse into the American frontier experience.

History of Defiance

Around the turn of the century, the little town of Defiance, MO was formed. This area had no name but big plans, as the Katy Railroad began installing a rail system through this region. The unnamed town needed a title with its progress and plans for further development.  Town officials wanted to use the name Parsons, after the man who laid the railroad. The name was quickly turned down due to another town on the Katy Line with the same label.  The Matson Brothers tried to stop the progress in this town, and thus the town was named “Defiance” because they defied the Matson’s and allowed progress to continue.

Defiance Schools

There are no local schools in Defiance due to the small nature of this community. Students living in this area attend the Warrenton school district. There are five public schools that are divided by age groups K-12th.  There are five elementary schools, two middles schools and one high school in Warrenton. Each of the elementary schools has around 450 students and the high school has 930.  The class sizes are rather small with 15 students per teacher.  By having smaller class sizes, Warrenton can ensure that their students are getting a quality education and get the one-on-one interaction that they need.

Contact us today at 314-282-8282 for more information about living in Defiance.

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