Defiance Missouri Real Estate

Defiance is a small town located just about 40 miles West of St Louis.  It has been dubbed the “The Gateway to Missouri Wine Country“, and with good reason as the region is known for having some of the best vineyards in the Midwest.   See all the current Defiance MLS listings below, or read more about living in Defiance.  If you'd rather you can also search by map.

Homes For Sale in Defiance, MO

44 Properties Found. Page 1 of 3

90.57 +/- Acres Of Open And Wooded Ground. Acce...

REDUCED 22% Photo of Listing #18007816

$1,766,115 Active

  • 90.57 Acres

Acreage & Farms

S Hwy 94, Defiance, MO

MLS® #18007816

90.57 +/- Acres Of Open And Wooded Ground. Access To The Katy Trail From The South End Of The Property, Some Of This Section Is In The Flood Plain. Located Near Klondike Park, Weldon Spring Conservation Area And Lost Valley Hiking Trails. Close To Several...

Opportunities Like This Are Rare To Come By. Th...

Photo of Listing #19034275

$1,344,000 Active

  • 5 Beds
  • 7 Baths
  • 3 Acres
  • 3,326 ft²

Residential

220 Northlind Dr, Defiance, MO

MLS® #19034275

Opportunities Like This Are Rare To Come By. This Magnificent, 13-yr Old Custom Built Estate, On A Scenic 2.86 Acre Private Lot Is Only 15 Min From Chesterfield. The Long Driveway, The Expansive Lawn, The Common Ground W/deer & Woods. Pull Up To The Courty...

This Gorgeous Home Is Located Minutes From Ches...

REDUCED 6% Photo of Listing #19006327

$1,265,000 Active

  • 4 Beds
  • 6 Baths
  • 3 Acres
  • 2,757 ft²

Residential

3 Lauderdale Lane, Defiance, MO

MLS® #19006327

This Gorgeous Home Is Located Minutes From Chesterfield Valley. Serenity Is Provided At This Peaceful Home Site In The Development Of, The Crossings At Lauderdale Estates. The Exterior Of This Home Has A "big Cedar Lodge" Timber Look And Provides An Enterta...

For Someone Looking For A Great Recreational Pi...

Photo of Listing #19031858

$1,247,000 Active

  • 86 Acres

Acreage & Farms

N/A, Defiance, MO

MLS® #19031858

For Someone Looking For A Great Recreational Piece Just Minutes From Anything You May Need, This Is The Place For You. Just A Short 15 Minute Drive To Hwy 64 Or Just A Short 10 Minute Drive To New Melle. It Is Also Just Minutes From Many Different Wineries ...

Amazing Price On This Beautifully Maintained Ho...

REDUCED 3% Photo of Listing #19017737

$900,000 Active

  • 4 Beds
  • 5 Baths
  • 4.45 Acres
  • 3,889 ft²

Residential

221 Northlind Dr, Defiance, MO

MLS® #19017737

Amazing Price On This Beautifully Maintained Home Sitting On A Private 4.45 Acre Lot W/woods, Sprinkler, Fabulous L Shaped Salt Water Pool W/pool House, Hot Tub, Paver Patio, Screened In Porch! Impeccably Maintained 35'x35' Detached Garage, Insulated, Drywa...

Looking For A Custom Build, Acreage, Privacy & ...

REDUCED 5% Photo of Listing #19053480

$899,900 Active

  • 6 Beds
  • 5 Baths
  • 3.35 Acres
  • 3,638 ft²

Residential

1144 August Lake Dr, Defiance, MO

MLS® #19053480

Looking For A Custom Build, Acreage, Privacy & A Pool? Look No Further! This 2 Year New Home Has All Of This And More. Gorgeous Full Brick And Stone Elevation 1 ½ Story Home With Over 5000 Sq. Ft. Of Living Space With Fantastic Features Throughout. 6 True B...

Only 13.6 Miles To Hwy 94/i64! 14.9 Miles To Hw...

REDUCED 3% Photo of Listing #19043730

$799,900 Active

  • 4 Beds
  • 4 Baths
  • 6.61 Acres
  • 3,773 ft²

Residential

19 Horn Cove Lane, Defiance, MO

MLS® #19043730

Only 13.6 Miles To Hwy 94/i64! 14.9 Miles To Hwy Z/i70! Custom Built! 1.5 Story! 6.61 Wooded Acres! Private 70 Acre Sub Lake W/a Private Dock! Newer Swim Spa! 22 X 20 Patio! Fire Pit! Brand New 300+ Sq Ft Deck! 36x28 3 Car Detached Garage W/an Attached 2 Ca...

37.74 Heavily Wooded Acres Just Off Of Hwy Dd I...

Photo of Listing #19016517

$755,000 Active

  • 37.74 Acres

Acreage & Farms

Old Colony Rd, Defiance, MO

MLS® #19016517

37.74 Heavily Wooded Acres Just Off Of Hwy Dd In Defiance. Near The Bush Wildlife Area, The Weldon Springs Wildlife Area, And Wine Country Exactly 10 Minutes From Hwy 40 & 94. City Water, Electric, Phone And High Speed Internet To The Site. Possible Small D...

Motivated Seller! Duplicate Listing Of Mls# 190...

REDUCED 1% Photo of Listing #19056866

$729,900 Active

  • 1.45 Acres
  • 5,100 ft²

Commercial & Indr.

125 Defiance Rd, Defiance, MO

MLS® #19056866

Motivated Seller! Duplicate Listing Of Mls# 19055297. Turnkey Business Opportunity With 4 Large King Suites! Former Inn At Defiance, Renovated In 2019, Near Wineries & Katy Trail. Stone 2-sided Fireplace & Open Entertaining Area. Large Wraparound Porch & Co...

Motivated Seller! Turnkey Business Opportunity ...

REDUCED 1% Photo of Listing #19055297

$729,900 Active

  • 4 Beds
  • 6 Baths
  • 1.45 Acres
  • 3,846 ft²

Residential

125 Defiance Rd, Defiance, MO

MLS® #19055297

Motivated Seller! Turnkey Business Opportunity With 4 Large King Suites! Former Inn At Defiance, Renovated In 2019, Near Wineries & Katy Trail. Stone 2-sided Fireplace & Open Entertaining Area With Plenty Of Natural Light. Large Wraparound Porch & Covered D...

Simply Amazing! This Huge 3 Bed/3.5 Bath Brick ...

Photo of Listing #18084213

$700,000 Active

  • 3 Beds
  • 4 Baths
  • 3.01 Acres
  • 3,398 ft²

Residential

321 Matts Way, Defiance, MO

MLS® #18084213

Simply Amazing! This Huge 3 Bed/3.5 Bath Brick Front Custom-built Ranch Rests Upon A Sprawling 3 Acre Gently Rolling Lot Backing To Woods. The Open Floorplan Greets You W/hardwood Flooring In The Entry & A Soaring Cathedral Ceiling Stretching Rising Above T...

This Is The Home That Could Be The Answer To Yo...

Photo of Listing #19068103

$650,000 Active

  • 4 Beds
  • 6 Baths
  • 3.27 Acres
  • 3,259 ft²

Residential

1244 Kohlers Lane, Defiance, MO

MLS® #19068103

This Is The Home That Could Be The Answer To Your Dreams. 1244 Kohlers Lane Is Located On A Private 3 Acre Site With A Tree Surround That Frames The Lawn Areas With Space For A Grand Pool And Endless Outdoor Fun. The Owners Carefully Selected Every Timeless...

Gorgeous Atrium Ranch In Desirable Francis Howe...

Photo of Listing #19066949

$599,900 Active

  • 4 Beds
  • 4 Baths
  • 3.37 Acres
  • 2,605 ft²

Residential

3650 Forest Edge Dr, Defiance, MO

MLS® #19066949

Gorgeous Atrium Ranch In Desirable Francis Howell Sd On 3.37 Acres Overlooking Forest Lake.over 4500 Sqft Of Living Space,this Home Is A Spacious Split Bdrm Floorplan W/finished Walkout Ll*4+ Bdrms*an Office*an Exercise Rm*2 Storage Spaces In Ll Both W/sink...

Spectacular 1.5sty Farmhouse Style Home, On 16 ...

REDUCED 2% Photo of Listing #19063910

$589,000 Active

  • 5 Beds
  • 3 Baths
  • 16.02 Acres
  • 3,302 ft²

Acreage & Farms

3675 Highway D, Defiance, MO

MLS® #19063910

Spectacular 1.5sty Farmhouse Style Home, On 16 Acres In Defiance! Bright & Open Floor Plan W/5 Bds, 2.5 Bths & 3300+ Sqft. Gleaming Wood Floors! Formal Dining Rm W/impressive Light Fixture & Archway; Spacious Kitchen W/ss Appliances, Breakfast Bar & Adjoini...

Spectacular 1.5sty Farmhouse Style Home, On 16 ...

REDUCED 2% Photo of Listing #19061009

$589,000 Active

  • 5 Beds
  • 3 Baths
  • 16.02 Acres
  • 3,302 ft²

Residential

3675 Highway D, Defiance, MO

MLS® #19061009

Spectacular 1.5sty Farmhouse Style Home, On 16 Acres In Defiance! Bright & Open Floor Plan W/5 Bds, 2.5 Bths & 3300+ Sqft. Gleaming Wood Floors! Formal Dining Rm W/impressive Light Fixture & Archway; Spacious Kitchen W/ss Appliances, Breakfast Bar & Adjoini...

Picturesque Entertainment Capitol! Nature At Yo...

NEW Photo of Listing #19069447

$578,900 Active

  • 4 Beds
  • 3 Baths
  • 3.61 Acres
  • 2,229 ft²

Residential

3809 Indian Ridge, Defiance, MO

MLS® #19069447

Picturesque Entertainment Capitol! Nature At Your Back Door. 3.6 Wooded Acres, Custom Atrium. Located Off I-64, Shopping, Dining & Entertainment Right In The Heart Of Wine Country. Spend Early Mornings Drinking Coffee, Basking In The Wonders Of Privacy & ...

Beautifully Designed Atrium Ranch Home On 3.5 ...

REDUCED 4% Photo of Listing #19039187

$560,000 Active

  • 4 Beds
  • 4 Baths
  • 3.45 Acres
  • 2,604 ft²

Residential

3816 Rooster Ridge Ln, Defiance, MO

MLS® #19039187

Beautifully Designed Atrium Ranch Home On 3.5 Private Acres, Features A Geothermal Heating & Cooling System. 4600 Square Foot, Open Floor Plan W/ First-floor Master Suite, Large His/her Closets, Laundry Room. The Great Room With Gas Fireplace Overlooks A...


Living in Defiance, MO

There are various places of importance in close proximity to Defiance; they are the Yellow Farmhouse Vineyard and Winery, Historic Daniel Boone Home and Boonesfield Village, and Frisella Nursery. Many people travel to this area to visit the historic site of Daniel Boone’s home.  This old home was constructed in the early 1800’s and has thick limestone walls. Listed as a home on the National Register of Historic Places, this extraordinary site is often frequented by those new to the area.  Today, this village is owned and run by the Lindenwood University.  It is one of the great sites that depict life in this time period and give a glimpse into the American frontier experience.

History of Defiance

Around the turn of the century, the little town of Defiance, MO was formed. This area had no name but big plans, as the Katy Railroad began installing a rail system through this region. The unnamed town needed a title with its progress and plans for further development.  Town officials wanted to use the name Parsons, after the man who laid the railroad. The name was quickly turned down due to another town on the Katy Line with the same label.  The Matson Brothers tried to stop the progress in this town, and thus the town was named “Defiance” because they defied the Matson’s and allowed progress to continue.

Defiance Schools

There are no local schools in Defiance due to the small nature of this community. Students living in this area attend the Warrenton school district. There are five public schools that are divided by age groups K-12th.  There are five elementary schools, two middles schools and one high school in Warrenton. Each of the elementary schools has around 450 students and the high school has 930.  The class sizes are rather small with 15 students per teacher.  By having smaller class sizes, Warrenton can ensure that their students are getting a quality education and get the one-on-one interaction that they need.

Contact us today at 314-310-9988 for more information about living in Defiance.

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