Defiance Missouri Real Estate

Defiance is a small town located just about 40 miles West of St Louis.  It has been dubbed the “The Gateway to Missouri Wine Country“, and with good reason as the region is known for having some of the best vineyards in the Midwest.   See all the current Defiance MLS listings below, or read more about living in Defiance.  If you'd rather you can also search by map.

Homes For Sale in Defiance, MO

41 Properties Found. Page 1 of 3

90.57 +/- Acres Of Open And Wooded Ground. Acce...

REDUCED 22% Photo of Listing #18007816

$1,766,115 Active

  • 90.57 Acres

Acreage & Farms

S Hwy 94, Defiance, MO

MLS® #18007816

90.57 +/- Acres Of Open And Wooded Ground. Access To The Katy Trail From The South End Of The Property, Some Of This Section Is In The Flood Plain. Located Near Klondike Park, Weldon Spring Conservation Area And Lost Valley Hiking Trails. Close To Several...

For Someone Looking For A Great Recreational Pi...

Photo of Listing #19031858

$1,247,000 Active

  • 86 Acres

Acreage & Farms

N/A, Defiance, MO

MLS® #19031858

For Someone Looking For A Great Recreational Piece Just Minutes From Anything You May Need, This Is The Place For You. Just A Short 15 Minute Drive To Hwy 64 Or Just A Short 10 Minute Drive To New Melle. It Is Also Just Minutes From Many Different Wineries ...

This Gorgeous Home Is Located Minutes From Ches...

REDUCED 6% Photo of Listing #19006327

$1,195,000 Active

  • 4 Beds
  • 6 Baths
  • 3 Acres
  • 2,757 ft²

Residential

3 Lauderdale Lane, Defiance, MO

MLS® #19006327

This Gorgeous Home Is Located Minutes From Chesterfield Valley. Serenity Is Provided At This Peaceful Home Site In The Development Of, The Crossings At Lauderdale Estates. The Exterior Of This Home Has A "big Cedar Lodge" Timber Look And Provides An Enterta...

Motivated Seller! Duplicate Listing Of Mls# 190...

REDUCED 3% Photo of Listing #19056866

$699,900 Active

  • 1.45 Acres
  • 5,100 ft²

Commercial & Indr.

125 Defiance Rd, Defiance, MO

MLS® #19056866

Motivated Seller! Duplicate Listing Of Mls# 19055297. Turnkey Business Opportunity With 4 Large King Suites! Former Inn At Defiance, Renovated In 2019, Near Wineries & Katy Trail. Stone 2-sided Fireplace & Open Entertaining Area. Large Wraparound Porch & Co...

Motivated Seller! Turnkey Business Opportunity ...

REDUCED 3% Photo of Listing #19055297

$699,900 Active

  • 4 Beds
  • 6 Baths
  • 1.45 Acres
  • 3,846 ft²

Residential

125 Defiance Rd, Defiance, MO

MLS® #19055297

Motivated Seller! Turnkey Business Opportunity With 4 Large King Suites! Former Inn At Defiance, Renovated In 2019, Near Wineries & Katy Trail. Stone 2-sided Fireplace & Open Entertaining Area With Plenty Of Natural Light. Large Wraparound Porch & Covered D...

Picturesque, Nature At Your Back Door. 3.6 Woo...

Photo of Listing #19080407

$577,900 Active

  • 4 Beds
  • 3 Baths
  • 3.61 Acres
  • 2,229 ft²

Residential

3809 Indian Ridge, Defiance, MO

MLS® #19080407

Picturesque, Nature At Your Back Door. 3.6 Wooded Acres, Custom Atrium. Located Off I-64, Shopping, Dining & Entertainment Right In The Heart Of Wine Country. Spend Early Mornings Drinking Coffee, Basking In The Wonders Of Privacy & Sunlit Spaces. Custom ...

Simply Amazing! Nestled Upon A Sprawling 3 Acre...

Photo of Listing #19088860

$519,000 Active

  • 5 Beds
  • 3 Baths
  • 3 Acres
  • 2,272 ft²

Residential

524 Rooster Ridge Ct, Defiance, MO

MLS® #19088860

Simply Amazing! Nestled Upon A Sprawling 3 Acre Lot, This Expansive 5 Bed/3 Bath Brick-front Atrium Ranch Features A Cathedral Ceiling Stretching Above The Great Room Where You'll Marvel At The Custom Marble Medallion Inlay At The Entry, A Toasty Fireplace ...

5bed/3full,2half Bath 1.5 Story Home Located On...

REDUCED 5% Photo of Listing #19083870

$500,000 Active

  • 5 Beds
  • 5 Baths
  • 3.02 Acres
  • 3,029 ft²

Residential

1354 Lake Hollow Dr, Defiance, MO

MLS® #19083870

5bed/3full,2half Bath 1.5 Story Home Located On A Stunning 3.02 Acres That Backs To Trees. Cozy Lr Boasts Crown Molding, Chair Rail W/wainscoting, Pass Thru Brick Gas Fireplace, Built-in Bookshelves & Dual Sliding Doors That Open To A Large Sunroom & Access...

Gracious, High End, Country Living With Nearly ...

Photo of Listing #19091158

$414,900 Active

  • 3 Beds
  • 2 Baths
  • 3.56 Acres
  • 2,755 ft²

Residential

163 Quail Run, Defiance, MO

MLS® #19091158

Gracious, High End, Country Living With Nearly 4,500 Sq. Ft. Of Living Space On 3.5 Acres. Move-in Ready With Fresh, Neutral Paint & Hardwood Flooring Through Most Of The Main Level; New Premium Carpeting In Secondary Bedrooms And The Lower Level. The Vault...

Welcome Home To Your Year Round Defiance Paradi...

Photo of Listing #20003470

$349,900 Active

  • 3 Beds
  • 3 Baths
  • 3.79 Acres
  • 2,775 ft²

Residential

4989 Highway D, Defiance, MO

MLS® #20003470

Welcome Home To Your Year Round Defiance Paradise. Fifteen Minutes To Local Wineries, And Just Outside Of Town This Gorgeous 3 Bedroom 3 Bathroom Home Sitting On Almost 4 Acres Of Wooded Paradise Is Waiting For You To Add Your Touches To Make This Your Home...

Tract 6 In Saddleback Subdivision - Defiance, M...

Photo of Listing #19019825

$249,750 Active

  • 9.99 Acres

Residential Lots

6 Aj Boone Ridge Trail, Defiance, MO

MLS® #19019825

Tract 6 In Saddleback Subdivision - Defiance, Mo - This Lot Is Located In The Beautiful Saddleback Subdivision. The Lot Is Totally Wooded And Private. This Lot Has Access To A 70 Acre Lake And A Dock Will Be Provided For This Lot. This Lot Has A Flat, Woode...

Js Clement Construction Is Now Offering 3 Plus ...

Photo of Listing #19086451

$235,000 Active

  • 4.24 Acres

Residential Lots

Lot 9 Auden Prairie, Defiance, MO

MLS® #19086451

Js Clement Construction Is Now Offering 3 Plus Acre Home Sites At Their New Residential Development Auden Prairie In St. Charles County. Outstanding Location Off Wilson Rd Near The Intersection Of Hwy D And Dd Between Defiance And Lake St. Louis. Auden Prai...

Build Your Dream Home On This Private, Wooded, ...

REDUCED 4% Photo of Listing #19006888

$229,900 Active

  • 5 Acres

Residential Lots

1 Boone Ridge Trail, Defiance, MO

MLS® #19006888

Build Your Dream Home On This Private, Wooded, Waterfront 5 Acre Lot In The Middle Of Scenic Missouri Wine Country. Saddleback Is A Clear, Stream Fed, 70 Acre Private Lake Stocked With Muskies , Large And Small Mouth Bass And Crappie.. Excellent Location C...

Js Clement Construction Is Now Offering 3 Plus ...

Photo of Listing #19086707

$225,000 Active

  • 4.74 Acres

Residential Lots

Lot 16 Auden Prairie, Defiance, MO

MLS® #19086707

Js Clement Construction Is Now Offering 3 Plus Acre Home Sites At Their New Residential Development Auden Prairie In St. Charles County. Outstanding Location Off Wilson Rd Near The Intersection Of Hwy D And Dd Between Defiance And Lake St. Louis. Auden Prai...

Js Clement Construction Is Now Offering 3 Plus ...

Photo of Listing #19086704

$225,000 Active

  • 3 Acres

Residential Lots

Lot 15 Auden Prairie, Defiance, MO

MLS® #19086704

Js Clement Construction Is Now Offering 3 Plus Acre Home Sites At Their New Residential Development Auden Prairie In St. Charles County. Outstanding Location Off Wilson Rd Near The Intersection Of Hwy D And Dd Between Defiance And Lake St. Louis. Auden Prai...

Js Clement Construction Is Now Offering 3 Plus ...

Photo of Listing #19086682

$225,000 Active

  • 3 Acres

Residential Lots

Lot 10 Auden Prairie, Defiance, MO

MLS® #19086682

Js Clement Construction Is Now Offering 3 Plus Acre Home Sites At Their New Residential Development Auden Prairie In St. Charles County. Outstanding Location Off Wilson Rd Near The Intersection Of Hwy D And Dd Between Defiance And Lake St. Louis. Auden Prai...

Js Clement Construction Is Now Offering 3 Plus ...

Photo of Listing #19086706

$210,000 Active

  • 3 Acres

Residential Lots

Lot 14 Auden Prairie, Defiance, MO

MLS® #19086706

Js Clement Construction Is Now Offering 3 Plus Acre Home Sites At Their New Residential Development Auden Prairie In St. Charles County. Outstanding Location Off Wilson Rd Near Intersection Of Hwy D And Dd Between Defiance And Lake St. Louis. Auden Prairie ...


Living in Defiance, MO

There are various places of importance in close proximity to Defiance; they are the Yellow Farmhouse Vineyard and Winery, Historic Daniel Boone Home and Boonesfield Village, and Frisella Nursery. Many people travel to this area to visit the historic site of Daniel Boone’s home.  This old home was constructed in the early 1800’s and has thick limestone walls. Listed as a home on the National Register of Historic Places, this extraordinary site is often frequented by those new to the area.  Today, this village is owned and run by the Lindenwood University.  It is one of the great sites that depict life in this time period and give a glimpse into the American frontier experience.

History of Defiance

Around the turn of the century, the little town of Defiance, MO was formed. This area had no name but big plans, as the Katy Railroad began installing a rail system through this region. The unnamed town needed a title with its progress and plans for further development.  Town officials wanted to use the name Parsons, after the man who laid the railroad. The name was quickly turned down due to another town on the Katy Line with the same label.  The Matson Brothers tried to stop the progress in this town, and thus the town was named “Defiance” because they defied the Matson’s and allowed progress to continue.

Defiance Schools

There are no local schools in Defiance due to the small nature of this community. Students living in this area attend the Warrenton school district. There are five public schools that are divided by age groups K-12th.  There are five elementary schools, two middles schools and one high school in Warrenton. Each of the elementary schools has around 450 students and the high school has 930.  The class sizes are rather small with 15 students per teacher.  By having smaller class sizes, Warrenton can ensure that their students are getting a quality education and get the one-on-one interaction that they need.

Contact us today at 314-310-9988 for more information about living in Defiance.

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