Defiance Missouri Real Estate

Defiance is a small town located just about 40 miles West of St Louis.  It has been dubbed the “The Gateway to Missouri Wine Country“, and with good reason as the region is known for having some of the best vineyards in the Midwest.   See all the current Defiance MLS listings below, or read more about living in Defiance.  If you'd rather you can also search by map.

Homes For Sale in Defiance, MO

33 Properties Found. Page 1 of 2

90.57 +/- Acres Of Open And Wooded Ground. Acce...

REDUCED 22% Photo of Listing #18007816

$1,766,115 Active

  • 90.57 Acres

Acreage & Farms

S Hwy 94, Defiance, MO

MLS® #18007816

90.57 +/- Acres Of Open And Wooded Ground. Access To The Katy Trail From The South End Of The Property, Some Of This Section Is In The Flood Plain. Located Near Klondike Park, Weldon Spring Conservation Area And Lost Valley Hiking Trails. Close To Several...

For Someone Looking For A Great Recreational Pi...

Photo of Listing #19031858

$1,247,000 Active

  • 86 Acres

Acreage & Farms

N/A, Defiance, MO

MLS® #19031858

For Someone Looking For A Great Recreational Piece Just Minutes From Anything You May Need, This Is The Place For You. Just A Short 15 Minute Drive To Hwy 64 Or Just A Short 10 Minute Drive To New Melle. It Is Also Just Minutes From Many Different Wineries ...

This Gorgeous Home Is Located Minutes From Ches...

REDUCED 6% Photo of Listing #19006327

$1,195,000 Active

  • 4 Beds
  • 6 Baths
  • 3 Acres
  • 2,757 ft²

Residential

3 Lauderdale Lane, Defiance, MO

MLS® #19006327

This Gorgeous Home Is Located Minutes From Chesterfield Valley. Serenity Is Provided At This Peaceful Home Site In The Development Of, The Crossings At Lauderdale Estates. The Exterior Of This Home Has A "big Cedar Lodge" Timber Look And Provides An Enterta...

Looking For A Custom Build, Acreage, Privacy & ...

REDUCED 2% Photo of Listing #19078211

$849,900 Active

  • 6 Beds
  • 5 Baths
  • 3.35 Acres
  • 3,638 ft²

Residential

1144 August Lake Dr, Defiance, MO

MLS® #19078211

Looking For A Custom Build, Acreage, Privacy & A Pool? Look No Further! This 2 Year New Home Has All Of This And More. Gorgeous Full Brick And Stone Elevation 1 ½ Story Home With Over 5000 Sq. Ft. Of Living Space With Fantastic Features Throughout. 6 True B...

Motivated Seller! Duplicate Listing Of Mls# 190...

REDUCED 1% Photo of Listing #19056866

$724,900 Active

  • 1.45 Acres
  • 5,100 ft²

Commercial & Indr.

125 Defiance Rd, Defiance, MO

MLS® #19056866

Motivated Seller! Duplicate Listing Of Mls# 19055297. Turnkey Business Opportunity With 4 Large King Suites! Former Inn At Defiance, Renovated In 2019, Near Wineries & Katy Trail. Stone 2-sided Fireplace & Open Entertaining Area. Large Wraparound Porch & Co...

Motivated Seller! Turnkey Business Opportunity ...

REDUCED 1% Photo of Listing #19055297

$724,900 Active

  • 4 Beds
  • 6 Baths
  • 1.45 Acres
  • 3,846 ft²

Residential

125 Defiance Rd, Defiance, MO

MLS® #19055297

Motivated Seller! Turnkey Business Opportunity With 4 Large King Suites! Former Inn At Defiance, Renovated In 2019, Near Wineries & Katy Trail. Stone 2-sided Fireplace & Open Entertaining Area With Plenty Of Natural Light. Large Wraparound Porch & Covered D...

Picturesque, Nature At Your Back Door. 3.6 Woo...

Photo of Listing #19080407

$577,900 Active

  • 4 Beds
  • 3 Baths
  • 3.61 Acres
  • 2,229 ft²

Residential

3809 Indian Ridge, Defiance, MO

MLS® #19080407

Picturesque, Nature At Your Back Door. 3.6 Wooded Acres, Custom Atrium. Located Off I-64, Shopping, Dining & Entertainment Right In The Heart Of Wine Country. Spend Early Mornings Drinking Coffee, Basking In The Wonders Of Privacy & Sunlit Spaces. Custom ...

Beautifully Designed Atrium Ranch Home On 3.5 ...

REDUCED 4% Photo of Listing #19039187

$535,000 Active

  • 4 Beds
  • 4 Baths
  • 3.45 Acres
  • 2,604 ft²

Residential

3816 Rooster Ridge Ln, Defiance, MO

MLS® #19039187

Beautifully Designed Atrium Ranch Home On 3.5 Private Acres, Features A Geothermal Heating & Cooling System. 4600 Square Foot, Open Floor Plan W/ First-floor Master Suite, Large His/her Closets, Laundry Room. The Great Room With Gas Fireplace Overlooks A...

This Beautiful Atrium Home Sits On The Top Of A...

Photo of Listing #19071003

$499,000 Active

  • 5 Beds
  • 3 Baths
  • 3 Acres
  • 2,272 ft²

Residential

524 Rooster Ridge Ct, Defiance, MO

MLS® #19071003

This Beautiful Atrium Home Sits On The Top Of A Hill Overlooking Maple, Ash And Other Hardwood Trees, Offering A View That Is A Feast For The Eyes All Year Long From The Large Multi-level Deck But An Absolute Treat In The Fall. With A Stunning Kitchen, A La...

Exceptional 10 Acres Backs To Weldon Spring Con...

Photo of Listing #19046478

$275,000 Active

  • 10 Acres

Residential Lots

10-acres E Wilderness Lane, Defiance, MO

MLS® #19046478

Exceptional 10 Acres Backs To Weldon Spring Conservation Area With Mature Woods With Great Building Site. Possibility Of A Small Lake Site. Lots Of Privacy And Only 15 Minutes From Weldon Springs Or Winghaven. 10 Acres Being Split Off From An Estate, With S...

37.74 Heavily Wooded Acres Just Off Of Hwy Dd I...

REDUCED 67% Photo of Listing #19016517

$250,000 Active

  • 10 Acres

Acreage & Farms

Old Colony Rd, Defiance, MO

MLS® #19016517

37.74 Heavily Wooded Acres Just Off Of Hwy Dd In Defiance. Near The Bush Wildlife Area, The Weldon Springs Wildlife Area, And Wine Country Exactly 10 Minutes From Hwy 40 & 94. City Water, Electric, Phone And High Speed Internet To The Site. Possible Small D...

Tract 6 In Saddleback Subdivision - Defiance, M...

Photo of Listing #19019825

$249,750 Active

  • 9.99 Acres

Residential Lots

6 Aj Boone Ridge Trail, Defiance, MO

MLS® #19019825

Tract 6 In Saddleback Subdivision - Defiance, Mo - This Lot Is Located In The Beautiful Saddleback Subdivision. The Lot Is Totally Wooded And Private. This Lot Has Access To A 70 Acre Lake And A Dock Will Be Provided For This Lot. This Lot Has A Flat, Woode...

Build Your Dream Home On This Private, Wooded, ...

REDUCED 4% Photo of Listing #19006888

$229,900 Active

  • 5 Acres

Residential Lots

1 Boone Ridge Trail, Defiance, MO

MLS® #19006888

Build Your Dream Home On This Private, Wooded, Waterfront 5 Acre Lot In The Middle Of Scenic Missouri Wine Country. Saddleback Is A Clear, Stream Fed, 70 Acre Private Lake Stocked With Muskies , Large And Small Mouth Bass And Crappie.. Excellent Location C...

Sitting On A Beautiful 1.2 Acre Lot That Backs ...

REDUCED 2% Photo of Listing #19044188

$199,000 Active

  • 2 Beds
  • 2 Baths
  • 1.17 Acres
  • 1,512 ft²

Residential

985 Highway Dd, Defiance, MO

MLS® #19044188

Sitting On A Beautiful 1.2 Acre Lot That Backs To Woods As Well As Open Ground, You Can Experience Country Living And Still Be Just Minutes From Town And Major Highways! This Set Back Cedar Ranch Home Offers A Bright And Airy Open Floorplan, New Flooring A...

Prime Defiance Location! What A Great Locatio...

REDUCED 5% Photo of Listing #19067814

$189,900 Active

  • 0.33 Acres
  • 1,364 ft²

Commercial & Indr.

2994 Highway 94 South, Defiance, MO

MLS® #19067814

Prime Defiance Location! What A Great Location For Your Business! Located In The Business District, Close To The Wineries And Fronting The Katy Trail. The Property Is Zoned Light Industrial And Encompassing Some Commercial Or Residential. This Is An Ideal...

Prime Defiance Location! Located In The Busine...

REDUCED 5% Photo of Listing #19066342

$189,900 Active

  • 2 Beds
  • 1 Baths
  • 0.33 Acres
  • 1,364 ft²

Residential

2994 Highway 94 South, Defiance, MO

MLS® #19066342

Prime Defiance Location! Located In The Business District, Close To The Wineries And Fronting The Katy Trail. The Property Is Zoned Light Industrial And Encompassing Some Commercial Or Residential. This Is An Ideal Location For A Small Business. On The Res...

Amazing View Of Wine Country! Across The Street...

REDUCED 7% Photo of Listing #19008676

$179,900 Active

  • 10 Acres

Residential Lots

485 Matson Hill Rd, Defiance, MO

MLS® #19008676

Amazing View Of Wine Country! Across The Street Is Matson Hill Park, Chandler Hill Winery Is Minutes Away, And The Katy Trail Is Approximately A Mile, This Property Has It All! Private But Still Close To St Louis County.


Living in Defiance, MO

There are various places of importance in close proximity to Defiance; they are the Yellow Farmhouse Vineyard and Winery, Historic Daniel Boone Home and Boonesfield Village, and Frisella Nursery. Many people travel to this area to visit the historic site of Daniel Boone’s home.  This old home was constructed in the early 1800’s and has thick limestone walls. Listed as a home on the National Register of Historic Places, this extraordinary site is often frequented by those new to the area.  Today, this village is owned and run by the Lindenwood University.  It is one of the great sites that depict life in this time period and give a glimpse into the American frontier experience.

History of Defiance

Around the turn of the century, the little town of Defiance, MO was formed. This area had no name but big plans, as the Katy Railroad began installing a rail system through this region. The unnamed town needed a title with its progress and plans for further development.  Town officials wanted to use the name Parsons, after the man who laid the railroad. The name was quickly turned down due to another town on the Katy Line with the same label.  The Matson Brothers tried to stop the progress in this town, and thus the town was named “Defiance” because they defied the Matson’s and allowed progress to continue.

Defiance Schools

There are no local schools in Defiance due to the small nature of this community. Students living in this area attend the Warrenton school district. There are five public schools that are divided by age groups K-12th.  There are five elementary schools, two middles schools and one high school in Warrenton. Each of the elementary schools has around 450 students and the high school has 930.  The class sizes are rather small with 15 students per teacher.  By having smaller class sizes, Warrenton can ensure that their students are getting a quality education and get the one-on-one interaction that they need.

Contact us today at 314-310-9988 for more information about living in Defiance.

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